N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide Brown solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts. Purity: ≥95% by HPLC. CAS 894804-07-0. Ref.: Vivanco, I., et al. 2007. Cancer Cell 11, 555. Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563. |
