N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide Tan solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38a, and a panel of more than 30 other kinases (pIC50 <5.0). In contrast, SP600125 (Cat. Nos. 420119 and 420128) offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions. Purity: ≥95% by HPLC. CAS 312917-14-9. Ref.: Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296.
R: 36/37/38; S: 26-36-45 |
