(3b, 23b)-17,23-Epoxy-3-hydroxyveratraman-11-one
11-Ketocyclopamine
Shh Signaling Antagonist III Off-white solid. PACKAGED UNDER INERT GAS. A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control. Purity: ≥98% by HPLC; single spot by TLC. RTECS WG9700000, CAS 469-59-0. Ref.: Williams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 4616. Cooper, M. K., et al. 2003. Nat. Genet. 33, 508. Mistretta, C.M., 2003. Dev. Biol. 254, 1. ten Berge, D., et al. 2001. Development 128, 2929. Cooper, M.K., et al. 1998. Science 280, 1603. |
