2,5-Dihydroxy-3-(1-methylindol-3-yl)-6-phenyl-1,4-benzoquinone Dark green solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent and highly selective activator of insulin receptor tyrosine kinase (IRTK; EC50 = 300 nM in CHO cells expressing human insulin receptor). Does not activate other closely related receptors such as insulin-like growth factor receptor (IGFIR), epidermal growth factor receptor (EGFR), and platelet-derived growth factor receptor (PDGFR) at concentrations up to 30 µM. Purity: ≥97% by HPLC. Ref.: Liu, K., et al. 2000. J. Med. Chem. 43, 3487. Qureshi, S.A., et al. 2000. J. Biol. Chem. 275, 36590. |
