White solid. PROTECT FROM LIGHT. Useful general cell-permeable protein kinase inhibitor. Potent inhibitor of CaM kinase II (K_i = 1.8 nM). Also inhibits myosin light chain kinase (K_i = 17 nM), protein kinase A (K_i = 18 nM), protein kinase C (K_i = 25 nM), and protein kinase G (K_i = 20 nM). Acts as a potent inhibitor (IC₅₀ = 3 nM) of the protein tyrosine kinase activity of the NGF receptor gp140^trk as well as the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp145^trkB and gp145^trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdk1 and Cdc25c. IC₅₀ = 35 nM for Flt3 autophosphorylation in Flt3/Itd-BaF3 cells. Purity: ≥95% by HPLC. RTECS NZ0550000, CAS 97161-97-2.

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