White solid. PROTECT FROM LIGHT. Potent, specific, cell-permeable inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. Does not significantly affect the activities of PKC, PKG, and MLCK. Inhibits axon branching in cultured neurons. Purity: ≥95% by HPLC. CAS 108068-98-0. Ref.: Simpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97. Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357. Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436. |
