3,4′,5,7-Tetrahydroxyflavone

Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Ab_25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Ab-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC₅₀ = 180 µM), and of transcriptional activation of COX-2 (IC₅₀<15 µM). Purity: ≥97% by HPLC. RTECS LK9275200, CAS 520-18-3.

Merck Index: 14, 5274
Ref.: Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287. Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451. Wang, H., et al. 2000. Phytomedicine 7, 15. Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945. Roth, A., et al. 1999. J. Neurosci. Res. 57, 399. Boege, F., et al. 1996. J. Biol. Chem. 271, 2262. Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.
R: 36/37/38-40; S: 22-26-36