4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid
Compound P
L165041 White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor d (PPARd) agonist (Ki = 6 nM for hPPARd and 730 nM for hPPARg). Potently induces adipocyte differentiation in NIH-PPARd cells at 500 nM and raises total cholesterol in insulin resistant db/db mice without altering glucose or triglycerides levels. Increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. Inhibits cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and the secretion of MCP-1 (monocyte chemotactic protein-1) in EAhy926 cells. Purity: ≥98% by HPLC. CAS 79558-09-1. Ref.: Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561. |
