1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine Off-white solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. A cell-permeable selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner. Purity: ≥95% by HPLC. CAS 127191-97-3. Ref.: Minami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199, 241. Kato, M., et al. 1992. Neurosci. Lett. 129, 47. Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1051. Ito, I., et al. 1991. Neurosci. Lett. 121, 119. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315. |
