2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine) Off-white solid. PROTECT FROM LIGHT. A cell-permeable inhibitor of rat brain CaM kinase II (Ki = 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH/3T3 cells. Purity: ≥95% by HPLC. CAS 139298-40-1. Ref.: Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39. Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608. Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
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