Omuralide White solid. A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. It is believed that in vitro, the natural product Lactacystin (Cat. No. 426100) acts as a precursor for clasto-lactacystin b-lactone and that the latter is the sole species that interacts with the proteasome. CAS 154226-60-5. Ref.: Corey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1. Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182. Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273. Fenteany, G., et al. 1995. Science 268, 726. |
