Galb,1,4Glc-Cer
LacCer
LC

Colorless solid. A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of p44 MAP kinase. Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase, and c-fos expression in human aortic smooth muscle cells. Purity: ≥98% by TLC. RTECS FK1000000, CAS 4682-48-8. M.W. 960.4 (based on tricosanoyl - 23:0).

Ref.: Bhunia, A.K., et al. 1997. J. Biol. Chem. 272, 15642. Bhunia, A.K., et al. 1996. J. Biol. Chem. 271, 10660. Zacharias, C., et al. 1994. J. Biol. Chem. 269, 13313.
R: 36/37/38; S: 26-36