Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos. Purity: ≥85% by HPLC. CAS 76343-93-6. Merck Index: 14, 8378
Ref.: Ayscough, K.R., et al. 1997. J. Cell Biol. 137, 399. Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127. Coue, M., et al. 1987. FEBS Lett. 213, 316. Schatten, G., et al. 1986. Exp. Cell Res. 166, 191. Spector, I., et al. 1983. Science 219, 493.
R: 20/21/22; S: 36 |
