a-Ltx White lyophilized solid. PROTECT FROM LIGHT. Causes massive release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates via Ca2+-dependent and -independent parallel mechanisms at concentrations as low as 100 pM. Stimulates Ca2+-independent GABA and glutamate release from cortical astrocytes in culture. Biological activity: Effective concentration: 100 pm-1 nm. Purity: One distinct band by SDS-PAGE. RTECS OE9020000, CAS 65988-34-3. Ref.: Parpura, V., et al. 1995. FEBS Lett. 360, 266. Storchak, L.G., et al. 1994. FEBS Lett. 351, 267. Osipenko, O.N., et al. 1993. Toxicon 31, 1123. Valtorta, F., et al. 1988. J. Cell Biol. 107, 2717. Grasso, A. 1976. Biochem. Biophys. Acta 439, 406. Frontali, B., et al. 1976. J. Cell Biol. 68, 462.
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