5-Amino-[(N-2,5-dihydroxybenzyl)-N′-2-hydroxybenzyl]salicylic Acid
RG14355 Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Cell-permeable inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and p60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 > 200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor (VEGF) in rats. Purity: ≥95% by HPLC. CAS 125697-92-9. Ref.: Hu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262. Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267. Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105. O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252. Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307. |
