5(S),12(R)-Dihydroxy-6-cis-8-trans-10-trans-14-cis-eicosatetraenoic Acid
LTB4 Clear oil. In Ethanol. Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium. Stimulates c-fos and c-jun proto-oncogene transcription in human monocytes. Involved in the pathogenesis of postischemic cerebral edema and asthma. Purity: >98% by HPLC. CAS 71160-24-2. Merck Index: 14, 5455
Ref.: Kendall, A.P., et al. 1995. Anesthesia 50, 590. Dokter, W.H., et al. 1994. Leukemia 8, 1181. Jedlitschky, G., et al. 1991. J. Biol. Chem. 266, 24763.
R: 11; S: 16-7 |
