(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one

Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism. Purity: ≥96% by HPLC. CAS 58749-22-7.

Ref.: Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653. Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793. Haraguchi, H., et al. 1998. Phytochemistry 48, 125. Park, E.J., et al. 1998. Planta Med. 64, 464. Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470. Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.
R: 20/21/22; S: 36