15(R)-LXA4
Aspirin-triggered LXA4
LXA4-15-epi
(5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid Liquid. In Ethanol. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-a-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin. Purity: ≥98% by HPLC. Caution! Product contains volatile liquid. Keep product cold at all times. CAS 171030-11-8. Ref.: Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323. Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223. Titos, E., et al. 1999. Am. J. Physiol. 277, C870. Gronert, K., et al. 1998. J. Exp. Med. 187, 1285. Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972. Claria, J., et al. 1996. Mol. Med. 2, 583. Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475. Serhan, C.N., et al. 1995. Biochemistry 34, 14609. |
