3′,4′,5,7-Tetrahydroxyflavone Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Purity: ≥90% by HPLC. RTECS LK9275210, CAS 491-70-3. Merck Index: 14, 5614
Ref.: Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151. Plaumann, B., et al. 1996. Oncogene 13, 1605. Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43. Shimoi, L., et al. 1994. Carcinogenesis 15, 2669. |
