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  InSolution™ LY 294002
Cat. No. 440204  
All Categories » Calbiochem » Inhibitors » Kinase and Phosphatase » Phosphatidylinositol 3-Kinase (PI3K)

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

Liquid. A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥98% by HPLC. CAS 154447-36-6.

Ref.: Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
R: 36/38; S: 26

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SolubilityMolecular FormulaMol. Wt.
 C19H17NO3 307.4 


Related Literature:

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440204: InSolution™ LY 294002 - English
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Related Categories:
All Categories » Calbiochem » Inhibitors » Kinase and Phosphatase » Phosphatidylinositol 3-Kinase (PI3K)

Selected Citations:
  1. Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
  2. Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
  3. Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
  4. Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
  5. Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
  6. Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
  7. Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
 
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