6-Anilino-5,8-quinolinequinone Reddish purple solid. A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors. Purity: ≥98% by TLC and HPLC. CAS 91300-60-6. Ref.: Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855. Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361. Beasley, D., et al. 1991. J. Clin. Invest. 87, 602. Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846. Light, D.B., et al. 1989. Science 243, 383. Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283. Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.
R: 22-36/37/38-45-46-48; S: 22-26-36/37/39-45 |
