2,6-bis(1,1-Dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol, HCl White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent antioxidant that readily crosses the blood-brain barrier. Significantly reduces ischemia-induced or hydrogen peroxide-induced neuronal damage and inhibits lipid peroxidation (IC50 = 22 µM). Prevents nuclear translocation of activated NF-kB in hippocampal neurons. Purity: ≥95% by HPLC. CAS 141545-89-3. Ref.: Toung, T.J., et al. 2000. Crit. Care Med. 28, 196. Fuson, K.S., et al. 1999. J. Neurochem. 72, 1154. Clemens, J.A., et al. 1998. Stroke 29, 677. Callaway, J.K., et al. 1998. J. Pharmacol. Toxicol. Methods 39, 155. O’Neill, M.J., et al. 1997. Brain Res. 760, 170. Clemens, J.A., et al. 1993. Stroke 24, 716. |
