(3a,4a,5a)-4-(2-Propenyl)cholestan-3-ol

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A novel hypocholesterolemic agent that reduces plasma cholesterol levels in animals by increasing the expression of hepatic low-density lipoprotein (LDL) receptors. However, recent studies have attributed the hypocholesterolemic activity of LY 295427 to its ability to reverse oxysterol-mediated suppression of sterol regulatory element-binding protein (SREBP) processing. Micromolar concentrations of this sterol restored the metabolism of LDL in oxysterol-treated cultured cells and inhibited the stimulation of cholesteryl ester synthesis mediated by oxysterols. Purity: ≥95% by TLC.

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