3-Methyl-1-phenyl-2-pyrazolin-5-one
Edaravone
PMP Cream-colored solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore. Purity: ≥98% by HPLC. RTECS UQ9625000, CAS 89-25-8. Merck Index: 14, 6713
Ref.: Katare, R. G., et al. 2003. Am. J. Physiol. 285, H2171. Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921. Yamamoto, Y., et al. 1996. Redox. Report 2, 333. Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597. Nishi, H., et al. 1989. Stroke 20, 1236.
R: 22-36/37/38-43; S: 26-36 |
