2-Benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)-2,3-dihydroisoindol-1-one White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable isoindolinone compound that binds to MDM2 and disrupts MDM2-p53 interaction (IC50 = 15.9 µM). Shown to upregulate p53-dependent luciferase activity and cellular levels of MDM2 and p21 in SJSA cells. Purity: ≥95% by HPLC. Ref.: Hardcastle, I.R., et al. 2006. J. Med. Chem. 49, 6209. Hardcastle, I.R., et al. 2006. Bioorg. Med. Chem. Lett. 15, 1515. |
