Brown solid. PROTECT FROM LIGHT. An antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells. Purity: ≥96% by HPLC. CAS 52665-74-4. Ref.: Kainuma, O., et al. 1997. Pancreas 15, 379. Nagase, T., et al. 1996. Int. J. Cancer 65, 620. Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333. Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281. Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349. |
