(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide
BiPS
BiPS Off-white solid. PACKAGED UNDER INERT GAS. A potent inhibitor of MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model. Purity: ≥95% by HPLC. Ref.: Lauzier, M.C., et al. 2008. Mol. Pharmacol. In press. Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592. Zhang, H., et al. 2004. Circ. Res. 95, 989. Tamura, Y., et al. 1998. J. Med. Chem. 41, 640. |
