FN-439 White solid. A tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC50 = 1.0 µM), MMP-9 (IC50 = 30 µM) and MMP-3 (IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE® Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase. Purity: ≥98% by HPLC. 4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl] Ref.: Hagemamn, T., et al. 2004. Carcinogenesis 25, 1543. Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442. |
