N-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-benzyloxycarbonylpiperazine-2-carboxamide White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC50 = 1.9 nM) and MMP-13 (IC50 = 1.3 nM). Inhibits MMP-1 and MMP-3 at higher concentrations (IC50 = 24 nM and 18 nM, respectively). Also acts as a weak inhibitor of MMP-7 (IC50 = 230 nM). Purity: ≥95% by HPLC. Ref.: Cheng, M., et al. 2000. J. Med. Chem. 43, 369. |