N-Hydroxy-2(R)-{[(4-methoxyphenyl)sulfonyl]-[benzylamino]}-4-methylpentanamide Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable p-methoxysulfonamido D-leucine-containing hydroxamate compound that acts as a potent inhibitor of human MMP-3 (stromelysin; Ki = 23 nM) and murine macrophage metalloelastase (MME/MMP-12; IC50 = 13 nM). Binds to the MMP active site Zn2+. Reported to inhibit the release of keratan sulfate and sulfated glycosaminoglycan due to MMP-3 in the knee joint by 65% after iv dosing (12.5 µg/Kg) in a rabbit acute cartilage degradation model. Purity: ≥98% by HPLC . Ref.: Jeng, A.Y., et al. 1998. Bioorg. Med. Chem. Lett. 8, 897. MacPherson, L.J., et al. 1997. J. Med. Chem. 40, 2525. | 
