Pyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide) Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor. Purity: ≥98% by HPLC. CAS 544678-85-5. Ref.: Engel, C.K., et al. 2005. Chem. Biol. 12, 181. |
