(S)-2-(4′-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid) Off-white solid. PROTECT FROM LIGHT. A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes. Purity: ≥98% by TLC. CAS 199850-67-4. Ref.: Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506. Zhou, Y.P., et al. 2005. Diabetes 54, 2612. Peterson, J.T., et al. 2001. Circulation 103, 2303. Spinale, F.G., et al. 1999. Circ. Res. 85, 364. |
