(2-((Isopropoxy)-(1,1′-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 > 50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel. Purity: ≥97% by HPLC. Ref.: Tuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14, 4260. Rossello, A., et al. 2004. Bioorg. Med. Chem. 12, 2441. |
