N-Acetyl-5-methoxytryptamine
5-Methoxy-N-acetyltryptamine

Off-white solid. PROTECT FROM LIGHT. A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Exhibits antioxidant properties. Has neuroprotective effects against Ab peptides. Inhibits rat cerebellar nitric oxide synthase (NOS). Also acts as a peroxynitrite scavenger. Purity: ≥98% by HPLC. RTECS AC5955000, CAS 73-31-4.

Merck Index: 14, 5816
Ref.: Pappolla, M.A., et al. 2002. J. Pineal Res. 32, 135. Reiter, R.J., and Tan, D.X. 2002. Ann. N.Y. Acad. Sci. 957, 341. Cuzzocrea, S., et al. 1998. J. Pineal Res. 25, 24. Maestroni, G.J., et al. 1994. Cancer Res. 54, 2429. Pozo, D., et al. 1994. Life Sciences 55, PL455.