2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable 1,4-naphthoquinone compound that acts as potent and selective inhibitor of MEK (IC50 = 0.38 µM for MEK1). It shows little effect on PKC and PKA, and inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 and 82.9 µM, respectively). Purity: ≥97% by HPLC . CAS 623163-52-0. Ref.: Bakare, O., et al. 2003. Bioorg. Med. Chem. 11, 3165. |
