Z-& E-a-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile
SL327 Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK1/2 (IC50 = 180 nM and 220 nM, respectively). Shown to inhibit AP-1 activity (IC50 = 2.03 µM). Inhibits ERK1, MKK3/p38, MKK4, JNK, and PKC activities at higher concentrations (IC50 > 10 µM). Reported to offer neuroprotection against ischemic brain injury in mice by selectively blocking ERK1/2 activation. Also suppresses IL-1b expression. Displays enhanced aqueous solubility compared to U0126 (Cat. No. 662005). Purity: ≥97% by HPLC. Supplied as a mixture of Z- and E-isomers. CAS 305350-87-2. Ref.: Hetman, M., et al. 2002. J. Biol. Chem. 277, 49577. Ohno, M., et al. 2001. Nat. Neurosci. 4, 1238. Wang, H., et al. 2001. Biochem. Biophys. Res. Commun. 286, 869. Scherle, P.A., et al. 2000. J. Biol. Chem. 275, 37086. Valjent, E., et al. 2000. J. Neurosci. 20, 8701. Watabe, A.M., et al. 2000. J. Neurosci. 20, 5924. Atkins, C.M., et al. 1998. Nat. Neurosci. 1, 602. |
