KiSS-1 (68-121)
Kisspeptin-54 White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A KiSS-1 gene product with 54 amino-acid residues and a C-terminally amidated LRF-motif that acts as a metastasis inhibitor via G-protein-coupled receptors (GPCRs). Reported to inhibit chemotaxis and invasion of hOT7T175-transfected CHO cells in vitro (IC50 = 50 nM) and attenuates pulmonary metastasis of hOT7T175-transfected B16-BL6 melanomas in vivo. Shown to be a potent and selective agonist of AXOR12 and hOT7T175 (a novel human GPCR). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells. Binds to hOT7T175 with high affinity (Ki = 340 pM, determined by competitive binding analysis). Purity: ≥95% by HPLC. H-Gly-Thr-Ser-Leu-Ser-Pro-Pro-Pro-Glu-Ser-Ser-Gly-Ser-Arg-Gln-Gln-Pro-Gly-Leu-Ser-Ala-Pro-His-Ser-Arg-Gln-Ile-Pro-Ala-Pro-Gln-Gly-Ala-Val-Leu-Val-Gln-Arg-Glu-Lys-Asp-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 Ref.: Kotani, M., et al. 2001. J. Biol. Chem. 276, 34631. Ohtaki, T., et al. 2001. Nature 411, 613. Muir, A.I., et al. 2001. J. Biol. Chem. 276, 28969. | 
