(+)-Amethopterin
4-Amino-10-methylfolic Acid
Methylaminopterin
MTX

Clear yellow to orange-brown solution. In sterile isotonic NaCl. USP grade. Each 25 mg/ml, 4 ml (100 mg) vial contains methotrexate sodium equivalent to 100 mg methotrexate. PROTECT FROM LIGHT. Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an antitumor agent. Purity: ≥95% by HPLC. RTECS MA1225000, CAS 59-05-2.

Merck Index: 14, 5985
Ref.: Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976. Takasuga, A., et al. 1992. J. Biochem. 112, 652. Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065. Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
R: 25-36/37/38-46-60-61; S: 26-36/37/39-45