MLA White crystalline solid. PROTECT FROM LIGHT. a-Bungarotoxin neuronal nicotinic receptor (nAChR) antagonist. Has high affinity (nM range) for a subtype of the neuronal acetylcholine receptor (nAchR) in the brain that probably incorporates the a7-subunit. Exhibits micromolar affinity for muscle acetylcholine receptor and for a-bungarotoxin-insensitive neuronal nAChR. Reconstitution experiments in Xenopus oocytes have shown the effects of methyllycaconitine on nAChR to be highly specific for the a7-subtype (IC50 = 0.1 nM), but not for the a3b4-subtype (IC50 = 1 µM). Can be used to distinguish between neuronal and muscular nicotinic receptors. Purity: >95% by TLC. Ref.: López, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184. Alkondon, M., and Albuquerque, E.X. 1994. Neurosci. Lett. 176, 152. Pereira, E.F., et al. 1993. J. Pharm. Exp. Ther. 265, 1474. Alkondon, M., et al. 1992. Mol. Pharmacol. 41, 802. Ward, J.M., et al. 1990. FEBS Lett. 270, 45.
R: 23/24/25; S: 36/37/39-45 |
