Compactin White solid. An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation. Inhibitor of myoblast fusion. Also may induce bone morphogenic protein-2 (BMP-2). Causes cell cycle arrest in late G1 phase. Purity: ≥95% by HPLC. This is an inactive form which may require activation for use with isolated cells depending upon the application. To activate, treat with NaOH in ethanol and then neutralize to pH 7.2. RTECS EK7907100, CAS 73573-88-3. Merck Index: 14, 6164
Ref.: Sugiyama, M., et al. 2000. Biochem. Biophys. Res. Commun. 271, 688. Hug, T., et al. 1995. Pflugers Archiv. Eur. J. Physiol. 429, 682. Belo, R.S., et al. 1993. Mol. Cell. Biochem. 126, 159. McLeish, K.R., et al. 1993. Biochem. Biophys. Res. Commun. 197, 763. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602. Jackson, J.H., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3042. Kita, T., et al. 1980. J. Clin. Invest. 66, 1094. |
