Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal
Z-LL-Nva-CHO White solid. PROTECT FROM LIGHT. Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells. Purity: ≥90% by HPLC. Z-Leu-Leu-Nva-CHO Ref.: Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893. Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280. Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761. Vinitsky, A., et al. 1992. Biochemistry 31, 9421. |
