Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
Z-LLL-CHO White solid. A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC50 = 3 µM). Prevents b-secretase cleavage. Purity: ≥98% by HPLC. CAS 133407-82-6. Z-Leu-Leu-Leu-CHO Ref.: Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761. |
