Return to our Home Page

Tech Resources
Data Sheet
MSDS - English
Other Languages
Selected Citations
Certificate of Analysis
Store
-20°C-20°C
Ship
Shipped with Blue Ice <br> Shipped with blue ice (water ice)!Blue ice
IrritantIrritant
Note: Store and Ship conditions may differ.
See Key

Inhibitor Email Sign Up

Inhibitor Resource

GSK-3 Signaling Interactive Pathway
   
Quick Order Shopping Cart
Email a Link to this Page Help
  InSolution™ MG-132
Cat. No. 474791  
All Categories » Calbiochem » Inhibitors » Protease » Proteasome and Ubiquitination

Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
Z-LLL-CHO

Liquid. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474790) in DMSO. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Purity: ≥98% by HPLC. CAS 133407-82-6.

Ref.: Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J.H.J., et al. 1996. Cell 84, 769. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761.
R: 36/38; S: 26-36-45

Need additional information about this product? Email our Technical Service department at: technical@calbiochem.com

 Related information for this product is available:
Additional information is available from the "Tech Resources"
box in the upper left panel of this page.

EMD Chemicals Inc. list price is displayed (pricing with local distributors may vary). NOTE: In Stock status is based on item availability worldwide.

Size
In Stock
Select Country Above
For Pricing Information
1 mgYN/A

SolubilityMolecular FormulaMol. Wt.
 C26H41N3O5 475.6 

Related Literature:

Caspases and other Apoptosis Related Tools Brochure
Inhibitor Sourcebook
Proteasome/Ubiquitination NF-kB Pathway Brochure

Material Safety Data Sheets:
474791: InSolution™ MG-132 - English
Bulgarian
Danish
Dutch
Finnish
French
German
Greek
Hungarian
Italian
Korean
Norwegian
Polish
Portuguese
Spanish
Swedish

Related Categories:
All Categories » Calbiochem » Inhibitors » Protease » Proteasome and Ubiquitination

Selected Citations:
  1. Yolanda Fernandez, et al. (2006) Chemical Blockage of the Proteasome Inhibitory Function of Bortezomib: Impact on Tumor Cell Death. Journal of Biological Chemistry 281, 1107-1118.
  2. Markus D. Lacher, et al. (2006) Transforming Growth Factor-{beta} Receptor Inhibition Enhances Adenoviral Infectability of Carcinoma Cells via Up-Regulation of Coxsackie and Adenovirus Receptor in Conjunction with Reversal of Epithelial-Mesenchymal Transition. Cancer Research 66, 1648-1657.
  3. Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
  4. Emily I. Chen, et al. (2005) Maspin alters the carcinoma proteome. FASEB Journal in press,.
  5. Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
  6. Zaibo Li, et al. (2005) VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1α. European Molecular Biology Organization Reports 6, 373-378.
  7. Yasuyuki Miyake, et al. (2005) Novel splicing variant of mouse orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Journal of Biological Chemistry 280, 12643-12652.
  8. Chuan-Jin Wu, et al. (2005) TNF-α induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. European Molecular Biology Organization Journal 24, 1886-1898.
  9. Zhigang Zhang, Jin-Ying Wu, William Hait and Jin-Ming Yang. (2004) Regulation of the stability of P-glycoprotein by ubiquitination.. Molecular Pharmacology 66, 395-403.
  10. Gloria Bonuccelli, et al. (2003) Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins. American Journal of Pathology 163, 1663-1675.
 
Change Country | Contact Us | Privacy Policy | Terms and Conditions
 
©2008 Calbiochem, Novabiochem, & Novagen
are brands of EMD Chemicals Inc., an Affiliate of Merck KGaA, Darmstadt, Germany.