White solid. Potent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 230 nM). Elevates the intracellular cGMP level without causing any change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isozymes. Purity: ≥98% by TLC. Ref.: Takase, Y., et al. 1994. J. Med. Chem. 37, 2106. |