(11b,17b)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Ab-, H2O2-, and glutamate-induced injury to mouse hippocampal HT22 cells. Purity: ≥99% by titration. Contaminants: Steroid substances: ≤0.1%. RTECS KG2955000, CAS 84371-65-3. Merck Index: 14, 6186
Ref.: McCullers, D.L., et al. 2002. Neuroscience 109, 219. Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159. Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524. Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469. Lam, F.C., et al. 2001. J. Neurochem. 76, 1121. Sridhar, S., et al. 2001. Cancer Res. 61, 7179. Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912. Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280. Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.
R: 60-61; S: 22-36/37/39-45 |
