Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin, Tetratosylate, Hydroxide Black solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2• oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants. Purity: ≥95% by TLC. Ref.: Izbicka, E., et al. 1999. Cancer Res. 59, 639. Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053. Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20. Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271. Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471. |
