3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic Acid, Na White solid. A cell-permeable, potent, and specific inhibitor of leukotriene biosynthesis (IC50 = 102 nM). Prevents the activation of 5-lipoxygenase by binding to 5-lipoxygenase-activating protein (FLAP); however, it does not affect 5-lipoxygenase activity in cell-free systems. Exhibits no effect on other pathways of arachidonic acid metabolism, including the cyclooxygenase, 12-lipoxygenase, and 15-lipoxygenase pathways. Purity: ≥99% by TLC. CAS 118414-82-7. Ref.: Ford-Hutchinson, A.W., et al. 1993. Can. J. Physiol. Pharmacol. 71, 806. Ford-Hutchinson, A.W., et al. 1991. Trends pharmacol. 71, 806. Dixon, R.A.F., et al. 1990. Nature 343, 282. Rouzer, C.A., et al. 1990. J. Biol. Chem. 265, 1436. |
