Off-white to beige solid. Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells. Purity: ≥98% by TLC. RTECS JH2830000, CAS 22373-78-0.

Merck Index: 14, 6246
Ref.: Inabayashi, M., et al. 1995. Biochemistry 34, 3455. Mendez, A.J. 1995. J. Biol. Chem. 270, 5891. Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta 1213, 193. Griffin, T., et al. 1993. J. Natl. Cancer Inst. 85, 292. Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res. 53, 658. Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta 1104, 123. Kok, J.W. 1992. J. Cell. Sci. 103, 1139. Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol. 44, 1395.
R: 26/27/28; S: 22-36/37/39-45