Brown solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells. Purity: ≥95% by HPLC. RTECS DG2580000, CAS 5351-17-7. Ref.: Engelmann, I., et al. 2000. Redox Report 5, 207. Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461. Burner, U., et al. 1999. J. Biol. Chem. 274, 9494. Kettle, A.J., et al. 1997. Biochem. J. 321, 503. Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
R: 36/37/38; S: 26-36 |
