2b,3b,5b,11a,14a,20R,22R-Heptahydroxycholest-7-en-6-one
MurA Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A phytoecdysteroid analog of ecdysone that acts as a potent inducer of ecdysone-inducible genes in mammalian cells and transgenic animals (Kd ~1 nM). Induces apoptosis (~5 µM) in cells transfected with wild-type Bax. Shown to regulate the metamorphosis of Drosophila melanogaster and induce the biological response of G2 cell cycle arrest. Purity: ≥99% by HPLC. CAS 38778-30-2. Ref.: Saez, E., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14512. Gil, J., et al. 1999. Cancer Res. 59, 2034. No, D., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3346. Landon, T. M., et al. 1988. J. Biol. Chem. 263, 4693. |
